Targeting Leishmania: Revisiting Leishmania Iron Transporter 1 (LIT1)
نویسندگان
چکیده
Intracellular pathogens are microorganisms that traverse the plasma membrane of a particular host cell...
منابع مشابه
Iron uptake controls the generation of Leishmania infective forms through regulation of ROS levels
During its life cycle, Leishmania undergoes extreme environmental changes, alternating between insect vectors and vertebrate hosts. Elevated temperature and decreased pH, conditions encountered after macrophage invasion, can induce axenic differentiation of avirulent promastigotes into virulent amastigotes. Here we show that iron uptake is a major trigger for the differentiation of Leishmania a...
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The protozoan parasite Leishmania is the causative agent of serious human infections worldwide. The parasites alternate between insect and vertebrate hosts and cause disease by invading macrophages, where they replicate. Parasites lacking the ferrous iron transporter LIT1 cannot grow intracellularly, indicating that a plasma membrane-associated mechanism for iron uptake is essential for the est...
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Infection of mammalian hosts with Leishmania amazonensis depends on the remarkable ability of these parasites to replicate within macrophage phagolysosomes. A critical adaptation for survival in this harsh environment is an efficient mechanism for gaining access to iron. In this study, we identify and characterize LIT1, a novel L. amazonensis membrane protein with extensive similarity to IRT1, ...
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Iron, an essential co-factor of respiratory chain proteins, is critical for mitochondrial function and maintenance of its redox balance. We previously reported a role for iron uptake in differentiation of Leishmania amazonensis into virulent amastigotes, by a mechanism that involves reactive oxygen species (ROS) production and is independent of the classical pH and temperature cues. Iron import...
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ژورنال
عنوان ژورنال: Biomedical Journal of Scientific and Technical Research
سال: 2021
ISSN: ['2574-1241']
DOI: https://doi.org/10.26717/bjstr.2021.34.005517